Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
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چکیده
منابع مشابه
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.
BACKGROUND HIV-infected individuals, even well controlled with combined antiretroviral therapy (cART), have systemic inflammation and comorbidities. Substance P (SP) is an undecapeptide, which mediates neurotransmission and inflammation through its cognate neurokinin 1 receptor (NK1R). Plasma SP levels are elevated in HIV-infected individuals. The FDA-approved antiemetic aprepitant, an NK1R ant...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2017
ISSN: 2379-3708
DOI: 10.1172/jci.insight.95893